万春华，博士，教授，博士生导师。江苏省“333高层次人才培养工程”和南通市“226高层次人才培养工程”培养对象，国家自然科学基金通讯评审专家。主要机体营养代谢及代谢性疾病发生发展的机制研究。主持国家自然科学基金面上项目2项和青年基金1项、以及江苏省教育厅面上项目和南通市科技项目多项。在国内外高水平研究期刊发表研究性论文60余篇，其中包括以主要作者在Science Advances、Oncogene、Cancer letters、Cells和Toxicology等杂志发表论文多篇，总影响因子超过180分，总引用超过2000次。授权发明专利5项，与国内外高水平研究机构存在密切合作。

招生方向：

代谢性疾病的分子发生机制

消化系统疾病的病例分子机制

代表论文：

1. Liu J, Wu H, Zhou L, Jin Q, Ji H, Hu B, Wu H, Chen T, Wang X, Hong J, Feng R, Zhang X, Zhou J, Zhang W, Wang X, Qu L*, Wan C*.DC-SIGN+ macrophages alleviate metabolic dysfunction-associated steatotic liver disease via fine-tuning TLR4 signaling and inflammatory secretory profiles.Metabolism. 2026 Feb;175:156453.(*通讯作者, IF = 16.7)

2. Zhang W, Lu W, Jiao Y, Li T, Wang H, Wan C*.Identifying disease progression biomarkers in metabolic associated steatotic liver disease (MASLD) through weighted gene co-expression network analysis and machine learning.Journal of Translational Medicine. 2025 Apr 24;23(1):472. doi: 10.1186/s12967-025-06490-7.(*通讯作者, IF = 9.7)

3. Jiao Y, Lu W, Wang X, Sun W, Hu B, Zhao J, Fang J, Lu Y*, Wan C*.Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways.iScience. 2025 Sep 4;28(10):113508.(*通讯作者, IF = 4.5)

4. Wan C, Yan X, Hu B, Zhang X. Emerging Roles of the Nervous System in Gastrointestinal Cancer Development. Cancers (Basel). 2022 Jul 30;14(15):3722.(第一作者, IF = 5.2)

5. Wan C, Gu T, Ling J, Qin Y, Luo J, Sun L, Hua L, Zhao J, Jiang S. Perfluorooctane sulfonate aggravates CCl4-induced hepatic fibrosis via HMGB1/TLR4/Smad signaling. Environmental Toxicology. 2022 May;37(5):983-994.

6. Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer. Science Advances. 2021 May 19;7(21):eabf2567.(第一作者, IF = 14.1)

7. Jiang Y, Gu L, Zhang Z, Zhao J, Wan C*. Severe Zinc Deficiency Causes the Loss and Apoptosis of Olfactory Ensheathing Cells (OECs) and Olfactory Deficit. Journal of Molecular Neuroscience. 2021 Apr;71(4):869-878.(*通讯作者)

8. Sun L, Wang X, Gu T, Hu B, Luo J, Qin Y, Wan C. Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. Toxicology. 2020 Aug;441:152502.

9. Hu B, Hua L, Ni W, Wu M, Yan D, Chen Y, Lu C, Chen B*, Wan C*. Nucleostemin/GNL3 promotes nucleolar polyubiquitylation of p27kip1 to drive hepatocellular carcinoma progression. Cancer Letters. 2017 Mar 1;388:220-229.(*通讯作者, IF = 11.8)

10. Wan C, Hou S, Ni R, Lv L, Ding Z, Huang X, Hang Q, He S, Wang Y, Cheng C, Gu XX, Xu G, Shen A. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. Oncogene. 2015 Jan 8;34(2):237-45.

科研项目：（近五年的）

1. CRISPR-Cas9全基因组筛选分析肝癌中NF-κB通路调控机制（81972279），国家自然科学基金面上项目，2020.01-2023.12，55.0万元，负责人, 已结题